Bio-Artificial Liver Support System: A Prospective Future Therapy

Whether acute or chronic, liver failure is a state of dysfunction that can progress to multiorgan failure. Mortality in patients approximately 80–90% and caused by detoxification failure, which triggers other immediate complications, such as encephalopathy, coagulopathy, jaundice, cholestasis, kidney The ideal treatment for transplantation, but the long waiting period right donor match causes unavoidable deaths most patients. Therefore, new therapies, tissue engineering, hepatocyte stem cells, are now being studied anticipate patient’s condition while transplantation. This literature review investigated effectiveness some bio-artificial support systems using methods systematically from international publication sites, including PubMed, keywords, liver, chronic extracorporeal system (ECLS), MARS, single-pass albumin dialysis (SPAD). Artificial bioartificial show specific abilities pathophysiological improvements cannot reach criteria actual function. must provide metabolic synthetic function reducing changes Aspects safety, cost efficiency, practicality also considered. Identifying technology produce high-quality hepatocytes on big scale essential medium replace failing cells. An increase capacity therapeutic focus patient survival ability perform